Hey! I'm working on a story that has aware/self-aware as the symptom/response for my MC throughline, so I'm familiar with these how these terms apply to my own story, but it's hard to discuss them in isolation. Remember, the symptom and response are in relation to the problem and solution.
In my story, the problem/solution pair in the MC throughline is Actuality/Perception. The main character is alive, wheras others think she is a ghost. Her problem stems from trying to force her actual self to align with what her friends and family perceive her to be. She does this because she sees her problem as being one of self-awareness. To insist on living as her actual self would be selfish. She tries to focus instead on what other people's needs and perceptions of her are, manifesting a self that they will like.
So you can see how this symptom/response pairing takes a central inequity of a difference between perception of someone and the reality of who that person is and presents it as one of (I'll just forgo my perceptions of myself in favor of others' perceptions of me to CREATE the right self).
But all that's very specific to MY story. It's hard to point you in the right direction here without a little more information about YOUR story. What are your throughlines' problem/solution pairings? Can you link the problem with the symptom in your mind?