It's really about what the cause of the story’s conflict is. Although asking yourself what is more explored or what the focus is can be helpful, sometimes those questions can be too subjective to be useful.
For example, you might guess that the OS Domain of The Matrix is Manipulation because of Cypher (the traitor) tricking everyone, and Agent Smith trying to convince Morpheus to give up Zion’s codes/location. But if you take those things away you still have this crazy war going on between Agents and rebels, both within the Matrix and without, which has escalated since Neo was identified as “The One”.
Or you might watch The Princess Bride and be so fascinated by the cool sword-fighting, chases, and battling the Fire Swamp terrors that you’d guess the OS Domain was Activities. But if you took those things away you’d still have this evil prince who’s plotting to start a war with a neighbouring country, and is willing to murder his Princess Bride to do it. (You’d also still have a sick kid unwilling to enjoy his grandfather’s wonderful book.)
So, in your own writing, as long as the underlying cause of your throughline’s conflict at the highest level is still the Domain, don’t worry about other stuff cropping up. It might just be storytelling, or it might fit with another part of your structure.
What other part of your structure? Well, if you consider the Issue level you’ll see a lot of Variations that fall under certain Domains but seem to be members of others. The Preconception and Attitude Variations, which both smack of Fixed Attitudes, come under external domains. The Situation variation is under Manipulation; and even Evidence (under Fixed Atittude) has an external aspect to it.
Thus you can see that Cypher’s treachery in The Matrix is an example of the Morality vs. Self Interest conflict at the Issue level, and also fits the OS Problem/Symptom/Response (disbelieving that they can win, he focuses on the temptation of going back to the happy “blue pill” life of the Matrix, and responds with a lack of conscience). But all of this still comes UNDER the grand scale Activities of war between man and machines, rebels and Agents, fighting to gain superiority.
Further reading, Narrative First articles mentioning Litmus Test: