I’ll give my answer, but still hoping experts like Jim will chime in.
Honestly for me what helps is to remember that Domains and Concerns are the real high level, almost simple stuff. Genres. The really cool stuff that might come up in an English lit class is usually at a lower level in Dramatica. (With some exceptions of course – something like Preconscious in Zootopia is different and deals with modern issues, so gets well-deserved attention. Or a different treatment, like how The Past & Memories are used in such a neat way Arrival.)
Also you can usually see the lower level conflicts (Issue & Problem) as existing within the higher level (Domain & Concern). Like why does it matter whose side of Civil War’s superhero-control debate you’re on when the superheroes’ activities aren’t causing any trouble? It doesn’t. It only matters within the scope of those activities.