What I meant is something I don't have any examples of, so i can't provide one.
But, in a movie like When Harry Met Sally the two of them start off as strangers and then fall in love. Same with Four Weddings and a Funeral.
But certainly there are movies where people start out friends and end as strangers, or enemies.
I think this is what happens in Sweet Smell of Success. The MC and IC start as friends, but the IC leaves at the end, thinking that the MC is a failure.