That depends on additional questions.
Through what lens are you looking at unemployment - personally or distantly? E.g. Is it happening to you, or your spouse, or to both of you, or everybody?
Also, is unemployment the real problem underneath these perspectives? Or is it a symptom of something else? Or possibly something that must be endured on the way to the real resolution? E.g.
- Problems start for your MC because he loses his job, thus Unemployment = Situation.
- Or the MC keeps losing jobs because he's always self-sabotaging himself, thus Unemployment = Psychology.
- Or everyone in the story is trying to become self-employed / business owners, thus they all endure a period of joblessness, thus Unemployment = OS Cost.
My point is that a Grand Argument Story contains an armada of themes, none of which tidily sum up the point of the narrative. Any story about 'unemployment' will naturally touch on other hot-button social themes, like technological advancement, business ethics, glass ceilings, family dynamics, gentrification, urban and rural development, legislation, etc etc etc. None of these have a one-to-one match with a specific item on the Dramatica Table, in the same way you don't find 'greed' or 'love' or other socially subjective topics on there.
The real question for yourself is: What do you want to say about unemployment? How do you want your audience to experience it?